| 摘要 |
<p>Compounds of the general formula (I) or pharmacologically acceptable salts thereof [wherein X is =CH- or =N-; Y is -NH-, -NR4-, -S-, -O-, -CH=N-, -N=CH-, -N=N-, -CH=CH-, or the like; R1 is lower alkoxy, amino, a nitrogenous heterocyclic group, or a hydroxyl group substituted with a heterocyclic group (wherein each group may be substituted); R2 is either a lower alkylamino or lower alkoxy group which may be substituted with aryl, or a lower alkoxy group substituted with a nitrogenous aromatic heterocyclic group; and R3 is aryl, a nitrogenous heterocyclic group, lower alkyl, lower alkoxy, lower cycloalkoxy, a hydroxyl group substituted with a nitrogenous heterocyclic group, or amino (wherein each group may be substituted), or alternatively, R3 and the substituent of Y may be united to form a lactone ring]. The compounds exhibit excellent PDE V inhibitory activity and are useful as preventive or therapeutic agents for various diseases due to dysfunction of the signal tranduction through cGMP.</p> |
