发明名称 |
PROCESS FOR PRODUCING CRYSTAL |
摘要 |
A process for producing crystals of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]-sulfinyl]benzimidazole <.>n'H2O (wherein n' is about 0 to about 0.1) or of a salt thereof, characterized by subjecting a solution or dispersion in an organic solvent of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]benz-imidazole <.>nH2O (wherein n is about 0.1 to about 1.0) to crystallization to crystallize out the target compound. This process is a simple process by which an optically active sulfoxide derivative can be efficiently and industrially mass-produced in high yield while attaining an extremely high enantiomer excess.
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申请公布号 |
WO0187874(A1) |
申请公布日期 |
2001.11.22 |
申请号 |
WO2001JP04014 |
申请日期 |
2001.05.15 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD.;HASHIMOTO, HIDEO;MARUYAMA, HIDEAKI |
发明人 |
HASHIMOTO, HIDEO;MARUYAMA, HIDEAKI |
分类号 |
A61K31/4439;A61P1/04;A61P35/00;C07D401/12;(IPC1-7):C07D401/12;A61K31/443 |
主分类号 |
A61K31/4439 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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