发明名称 |
PROCESS FOR PREPARING N-[5-(DIPHENYLPHOSPHINOYLMETHYL)-4-(4-FLUOROPHENYL)-6-ISOPROPYLPYRIMIDIN-2-YL]-N-METHYLMETHANESULPHONAMIDE |
摘要 |
N-(5-(diphenylphosphinoylmethyl)-4-(4-fluorophenyl)-6- isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide (I) is prepared by reaction of (4-(4- fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonyl-aminopyrimidin- 2-yl)methanol (II) with chlorodiphenylphosphine (III). Preparation of N-(5-(diphenylphosphinoylmethyl)-4-(4-fluorophenyl)-6- isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide of formula (I) comprises the reaction of (4-(4- fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonyl-aminopyrimidin- 2-yl)methanol of formula (II) with (III). Ph = phenyl; and Ph' = 4-fluorophenyl. |
申请公布号 |
PL195166(B1) |
申请公布日期 |
2007.08.31 |
申请号 |
PL20000338944 |
申请日期 |
2000.03.10 |
申请人 |
LONZA AG |
发明人 |
BRIEDEN WALTER;VEITH ULRICH |
分类号 |
C07B61/00;C07F9/6512;A61K31/505;C07C25/13;C07D239/42;C07D239/84;C07F;C07F9/53;C07K |
主分类号 |
C07B61/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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