| 摘要 |
FIELD: organic chemistry. SUBSTANCE: invention relates to derivatives of piperazine of the formula (I) <EMI ID=0.69 HE=12 WI=51 TI=CHI> where Q - phenyl, naphthyl, pyridyl, pyrimidyl, furyl, isoquinolinyl, benzofuranyl, dihydrobenzofuranyl, benzyl, diphenylmethyl possibly substituted with 1 or more substituents taken from alkyl, alkoxyl, trifluoromethyl, dialkylamino, halogen, cyano- and ethylenedihydroxy-group; R - groups of the formula (a) <EMI ID=0.70 HE=27 WI=39 TI=CHI> and (b) <EMI ID=0.71 HE=18 WI=33 TI=CHI> where R and R are C<SB>1-6</SB>-alkoxyl or methylenedihydroxy-group; G is C<SB>3-6</SB>-cycloalkyl, phenyl, benzoyl, benzylcarbonyl, alpha-hydroxybenzyl, pyrrolyl where nitrogen atom has hydrogen atom or alkyl or takes part in binding with R, alkyl group substituted with heterocyclic group (thienyl, imidazolyl); alkanoylamino-group, morpholinoalkyl, 1-alkylindole-2-yl-group, phenylalkyl. Compounds of the formula (I) can be used as a drugs at different diseases of circulation organs or cerebral region, in part, that's caused by an excessive activation of calmodulin. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 13 cl, 6 tbl, 123 ex |
