| 发明名称 |
ANTITUBERCULAR COMPOSITION COMPRISING RIFAMPICIN, ISONIAZID, ETHAMBUTOL AND PYRAZINAMIDE AND ITS PROCESS OF PREPARATION |
| 摘要 |
The present invention relates to a monolayer tablet for use in the treatment of tuberculosis comprising a mixture of: granules comprising isoniazid, pyrazinamide, ethambutol or a pharmaceutically acceptable salt thereof and at least one granulation binder, rifampicin in powder form, extragranular excipients, wherein all of the granules have a particle size that is less than 0.599 mm, preferably less than 0.5 mm, more preferably less than 0.422 mm, and to its process of preparation. |
| 申请公布号 |
US2016158226(A1) |
申请公布日期 |
2016.06.09 |
| 申请号 |
US201414906870 |
申请日期 |
2014.07.22 |
| 申请人 |
SANOFI |
发明人 |
AMITH Kumar;BINDU Madavan;KUM Prasad;PRAVEEN Khullar |
| 分类号 |
A61K31/496;A61K9/20;A61K31/133;A61K31/4409;A61K31/4965 |
主分类号 |
A61K31/496 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. Monolayer tablet for use in the treatment of tuberculosis comprising a mixture of:
granules comprising isoniazid, pyrazinamide, ethambutol or a pharmaceutically acceptable salt thereof and at least one granulation binder, rifampicine in powder form, extragranular excipients,wherein all of the granules have a particle size that is less than 0.599 mm, preferably less than 0.5 mm, more preferably less than 0.422 mm. |
| 地址 |
Paris FR |
