| 发明名称 |
HUMAN MONOCLONAL ANTIBODIES AGAINST OREXIN RECEPTOR TYPE 1 |
| 摘要 |
The present disclosure relates to human monoclonal antibodies against orexin receptor type 1 (OX1R, hyprocretin 1) and uses thereof for the treatment of cancer. The antibodies are characterized by their CDRs: NYYMN,YISGSSRNIYYADFVKG,SNYDGMDV (Heavy chain) and AGTSSDVGGSNYVS, PGKAP, SSYTYYSTRV (Light Chain) ) or the CDRS having at least 50% or 70% identity with the above listed sequences. |
| 申请公布号 |
WO2016113356(A1) |
申请公布日期 |
2016.07.21 |
| 申请号 |
WO2016EP50677 |
申请日期 |
2016.01.14 |
| 申请人 |
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE);UNIVERSITÉ PARIS DIDEROT - PARIS 7;INSTITUT RÉGIONAL DU CANCER DE MONTPELLIER;UNIVERSITÉ DE MONTPELLIER |
发明人 |
COUVINEAU, ALAIN;VOISIN, THIERRY;NICOLE, PASCAL;ROBERT, BRUNO;MARTINEAU, PIERRE;CHENTOUF, MYRIAM |
| 分类号 |
C07K16/28;A61K39/00;C07K16/30 |
主分类号 |
C07K16/28 |
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