发明名称 |
Matrix metalloproteinase inhibitors. |
摘要 |
Succinic amide derivatives of formula (I), wherein W is a -CO2H or -CONHOH group; R, R1 and R2 are each hydrogen or an organic residue, R3 is the residue of an alpha-aminoacid and R4 is an organic group, are inhibitors of matrix metalloproteinases (MMPs) and of the release of tumor necrosis factor-alpha (TNF) from cells, and are therefore useful in the prevention, control and treatment of diseases in which MMPs or TNF are involved. A process for their preparation and pharmaceutical compositions containing them are also described. |
申请公布号 |
ZA9705631(B) |
申请公布日期 |
1998.01.30 |
申请号 |
ZA19970005631 |
申请日期 |
1997.06.25 |
申请人 |
PHARMACIA & UPJOHN S.P.A. |
发明人 |
MARCO ALPEGIANI;FRANCESCA ABRATE;PIERLUIGI BISSOLINO;MASSIMILIANO PALLADINO;ETTORE PERRONE |
分类号 |
C07D295/12;A61K31/16;A61K31/426;C07C237/22;C07C259/06;C07C271/22;C07C311/19;C07D213/38;C07D213/40;C07D213/75;C07D277/20;C07D277/44;C07D295/18;C07D295/22;C07D317/66;C07D487/04;C07D487/08 |
主分类号 |
C07D295/12 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|