| 摘要 |
The invention comprises compounds of the formula: <FORM:1035173/C2/1> wherein R represents hydrogen, a C1- 4 alkyl group, or an aralkyl group, the alkyl moiety of which contains at most 4 carbon atoms, Z represents a straight or branched chain C2- 6 alkylene group, and Am represents a dialkylamino group, each alkyl radical of which contains at most 4 carbon atoms and which alkyl radicals may be bound to each other direct or by way of a C1- 4 alkylimino group, or it represents a C1- 4 alkylamino group; acid addition salts thereof; and a process for their preparation comprising hydrogenating a compound of the formula: <FORM:1035173/C2/2> wherein Am1 represents an N-arylmethyl-alkyl-amino group, the alkyl moiety of which contains at most 4 carbon atoms, or a dialkylamino group, each alkyl group of which contains at most 4 carbon atoms and which alkyl radicals may be bound to each other direct or by way of a C1- 4 alkylimino group and R1 represents a C1- 4 alkyl group or an aralkyl group, the alkyl moiety of which contains at most 4 carbon atoms, until essentially double the molar amount or, if there is an arylmethyl radical in Am1, triple the molar amount of hydrogen has been taken up and, if desired, splitting off the radical R1 by acidolysis and/or, if desired, reacting a resulting compound of Formula I in which Am represents a dialkylamino radical with a carbonic acid monoester halide or with phosgene and hydrolysing or hydrogenolysing the resulting compound. Pharmaceutical compositions having reserpinantagonistic, anti-convulsive and anti-allergic activity, for oral or parenteral administration, comprise a compound of the invention together with a pharmaceutical carrier. The compositions may be in the form of aqueous solutions. |
