METHOD FOR PREPARING 4-AMINO PHENYL ACETE AMIDE DERIVATIVES

摘要

The 4-aminophenylaceteamide derivatives or pharmaceutically acceptable salts thereof are shown by the following structure formula(I). In this formula, X is hydrogen, halogen, hydroxy or methoxy, R is (CH2)nR1, where n is 1 to 19, R1 is methyl or benzene ring unsubstituted or substituted with halogen, methylenedioxy, trifluoromethyl, alkyl or alkoxy. Y is amino unsubstituted or substituted with acyl, alkyl, aminoalkyl, aminocarbonyl or amino thiocarbonyl and a ring can be formed, when alkyl or aminoalkyl is substituted. The compound of the following general formula(I) is prepared by the steps of: (i)reacting a 4-aminophenyl acetic acid of the following structure formula(II-a) and an amine compound of the following general formula(III) to obtain a compound of the following structure formula(IV), and then (ii)introducing an amino substituent into the structure formula(IV).