| 摘要 |
The invention provides an article of manufacture comprising a substantially non-immunogenic knee meniscal heterografts for implantation into humans. The invention further provides a method for preparing a knee meniscal heterograft by removing at least a portion of a meniscus from a non-human animal to provide a heterograft; washing the heterograft in saline and alcohol; subjecting the heterograft to at least one treatment selected from the group consisting of exposure to ultraviolet radiation, immersion in alcohol, ozonation, freeze/thaw cycling, and optionally to chemical crosslinking. In accordance with the invention the heterograft has substantially the same mechanical properties as the native xenogeneic meniscus.
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