RIBOZYMES CAPABLE OF CONFERRING RESISTANCE TO POTYVIRUS INFECTION, AND PLANTS EXPRESSING SAID RIBOZYMES

摘要

The invention concerns a nucleic acid molecule, called polyribozyme, having endoribonuclease activity, comprising at least first and second hybridising regions and at least two catalytic regions, said first and second hybridizing regions being complementary to first and second target regions, respectively, in the genomic (+) RNA of a potyvirus, or in the replicative (-) strand RNA of a potyvirus, said first and second target regions being either: within or comprising different genes or untranslated regions on the same RNA strand, or on different RNA strands, or within a region corresponding to one gene or cistron on the replicative (-) strand RNA.