USE OF A SOLUBLE RECOMBINANT HUMAN CD40L PROTEIN FOR INHIBITING IN VIVO IMMUNE RESPONSE

摘要

The invention relates to a method for inhibiting in vivo immune response and to the use of a soluble recombinant human CD40L or a sequence within said soluble recombinant human CD40L containing the active binding site with CD40 for inhibiting an immune response. The invention also relates to a mouse model of human alloimmunization for testing in vivo effects of an immunotherapy or inhibition of a human antibody response.