Substituted heterocyclic benzocycloalkenes and their use as an analgesic

摘要

Aminomethyl substituted heterocyclic benzocycloalkene derivatives (I) are new. Aminomethyl substituted heterocyclic benzocycloalkene derivatives of formula (I) and their salts are new: R<1> = OH; 1-6C alkoxy; or 3-7C cycloalkyloxy; R<2> = 1-6C alkyl; R<3> = 1-6C alkyl; aryl-1-2C alkyl; heterocyclyl-1-2C alkyl; -CH2-CH=C(R<6>)2; or 3-7C cycloalkyl-methyl; R<4>, R<5> = H; Cl; F; CF3; 1-6C alkyl; OH; 1-6C alkoxy; 3-7C cycloalkyloxy; alpha , beta or beta , gamma -O-(CH2)o-O-; -(CH2)n-aryl; heterocyclyl; -O-(CH2)n-aryl; or alpha , beta - or beta , gamma -benzo optionally mono- or disubstituted by F, Cl, CF3, OH, 1-6C alkyl, 1-6C alkoxy or -CON(R<6>R<7>); R<6> = H or 1-6C alkyl; R<7> = H; 1-6C alkyl; -(CH2)naryl; or CH2-3-7C cycloalkyl; or R<6> + R<7> = -(CH2)m or -(CH2)2-O-(CH2)2-; X = O; S; SO; or SO2; Y = -(CH2)0; -CH2-C(CH3)2-; or -C(CH3)2-; n = 0-2; m = 5-7; o = 1-2. An Independent claim is included for the preparation of compounds (I).