| 摘要 |
The present invention provides a compound having sPLA2 inhibiting activity.The compound represented by the formula (I):wherein R<1 >is (a) C1 to C20 alkyl, C2 to C20 alkenyl, C2 to C20 alkynyl, carbocyclic groups, heterocyclic groups or the like; R<2 >is COCONH2 or the like; Q<1 >is a nitrogen atom or C-R<4>; one of R<3 >and R<4 >is -(L<2>)-(acidic group) wherein L<2 >is a group connecting with an acid group and the length of the connecting groups 1 to 5 atoms, and the other is a hydrogen atom; R<21 >and R<22 >are hydrogen atoms or the like; X is -CR<23>R<24>- or the like wherein R<23 >and R<24 >are hydrogen atoms or the like; Y is -CR<25>R<26>- or the like wherein R<25 >and R<26 >are hydrogen atoms or the like; Z is CH2 or the like; a broken line ( - - - ) represents the presence or absence of a bond,its prodrug, their pharmaceutically acceptable salt, or solvate thereof. |
