MELANIN-CONCENTRATING HORMONE ANTAGONIST

摘要

A melanin-concentrating hormone antagonist which contains a compound represented by the formula or a salt thereof: (I) wherein R represents hydrogen, halogeno, or an optionally substituted cyclic group; X represents a bond or a spacer in which the main chain has one to ten atoms; Y represents a spacer in which the main chain has one to six atoms; ring A represents a benzene ring which may have other substituent(s); ring B represents a five- to nine-membered nitrogenous nonaromatic heterocycle which may have other substituent(s); and R<1> and R<2> are the same or different and each represents hydrogen, an optionally substituted hydrocarbon group, or an optionally substituted heterocyclic group, or R<1> and R<2> may form an optionally substituted nitrogenous heterocycle in cooperation with the adjacent nitrogen atom and R<2> may form an optionally substituted nitrogenous heterocycle in cooperation with the adjacent nitrogen atom and Y. The antagonist is useful as a preventive/remedy for adiposity, etc.