MULTIFUNCTIONAL POLYPEPTIDES COMPRISING A BINDING SITE TO AN EPITOPE OF THE NKG2D RECEPTOR COMPLEX
摘要
The present invention relates to a multifunctional polypeptide comprising a first domain comprising a binding site specifically recognizing an extracellular epitope of the NKG2D receptor complex and a second domain having receptor or ligand function. Furthermore, the present invention relates to polynucleotides encoding the multifunctional polypeptide, to vectors comprising said polypeptides and to cells comprising said polynucleotides or said vectors. The invention also relates to compositions comprising either of the above recited molecules, alone or in combination, as well as to specific medical uses of the multifunctional polypeptide of the invention.
申请公布号
WO0171005(A3)
申请公布日期
2002.01.03
申请号
WO2001EP03414
申请日期
2001.03.26
申请人
KUFER, PETER;RIETHMUELLER, GERT;LUTTERBUESE, RALF;BORSCHERT, KATRIN;KISCHEL, ROMAN;MAYER, MONIKA;HOFMEISTER, ROBERT
发明人
KUFER, PETER;RIETHMUELLER, GERT;LUTTERBUESE, RALF;BORSCHERT, KATRIN;KISCHEL, ROMAN;MAYER, MONIKA;HOFMEISTER, ROBERT