摘要 |
The present invention relates generally to a sphingosine kinase variant and to derivatives, analogues, chemical equivalents and mimetics thereof exhibiting reduced catalytic activity and, more particularly, to sphingosine kinase variants which exhibit a reduced capacity to phosphorylate sphingosine to sphingosine-1-phosphate. The present invention also contemplates genetic sequences encoding said sphingosine kinase variants and derivatives, analogues and mimetics thereof. The variants of the present invention are useful in a range of therapeutic and prophylactic applications.
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申请人 |
MEDVET SCIENCE PTY LTD;PITSON, STUART;MORETTI, PAUL;ZEBOL, JULIA;XIA, PU;GAMBLE, JENNIFER;VADAS, MATHEW;D'ANDREA, RICHARD;WATTENBERG, BINKS |
发明人 |
PITSON, STUART;MORETTI, PAUL;ZEBOL, JULIA;XIA, PU;GAMBLE, JENNIFER;VADAS, MATHEW;D'ANDREA, RICHARD;WATTENBERG, BINKS |