发明名称 N-(HETEROARYL)-1H-INDOLE-2-CARBOXAMIDE DERIVATIVES AND THEIR USE AS VANILLOID TRPV1 RECEPTOR LIGANDS
摘要 The invention concerns compounds of general formula (I), wherein: n is equal to 0, 1, 2 or 3; X1, X2, X3, X 4, Z1, Z2, Z3, Z4 and Z5 represent a hydrogen atom or certain specific substituents; W represents a fused bicyclic group of formula (a), bound to the nitrogen atom by positions 1, 2, 3 or 4; A represents a 5 to 7-membered optionally substituted heterocycle comprising one to three heteroatoms selected among O, S or N. Said compounds are ligands of the TRPV1 vanilloid receptor useful for treating pain and inflammation.
申请公布号 KR20070094833(A) 申请公布日期 2007.09.21
申请号 KR20077018041 申请日期 2006.01.04
申请人 SANOFI-AVENTIS 发明人 DUBOIS LAURENT;EVANNO YANNICK;MALANDA ANDRE
分类号 C07D403/12;A61K31/33;C07D401/12;C07D405/12 主分类号 C07D403/12
代理机构 代理人
主权项
地址