| 摘要 |
Novel compounds of formula <FORM:1107677/C2/1> wherein R1 is H, C1- 4 alkyl or benzyl, R2 and R3 are C1- 4 alkyl or phenyl, n is 1, 2 or 3 and X and Y are each H, C1- 5 alkyl, hydroxy-(C1- 5-alkyl), C1- 5 acyloxy-(C1- 5 alkyl), carbamyloxy-(C1- 5 alkyl) or phenyl-(C1- 5 alkyl) or together with the nitrogen atom to which they are attached form an optionally substituted heterocyclic ring of up to 8 members, and acid addition salts thereof, are prepared by reaction of the base HNXY and a halide of formula <FORM:1107677/C2/2> Haloketones of the last formula above are prepared either by addition of the 3-unsubstituted pyrrole to ethyl magnesium bromide followed by a compound of formula Cl(CH2)n.COCl, or by reaction of the 3-unsubstituted pyrrole with a compound of formula Cl(CH2)nCN in the presence of hydrogen chloride. 1,2-Dimethyl-5-phenylpyrrole is prepared by reaction of methylamine and 2-phenyl-pentane-1,4-dione. Pharmaceutical compositions comprise an above novel compound and a carrier therefor and are useful as tranquillizers, antidepressants, analgesics and hypotensives. |
