| 摘要 |
Thieno (3, 2-c) quinolines of formula (I) and their non-toxic salts: - R = H, lower alkyl; X = halogen, lower alkoxy. - As analgesic, antiinflammatory, and antipyretic agents of low toxicity. - A mixture of 4-allylthio-6-chloroquinoline (10 pts.) and PhNMe2 (30 pts.) is refluxed for 2 1/2 hours. Solvent is removed by distn. and the residue is chromatographed on Al2O3, eluting with benzene, to yield 2-methyl-8-chloro-2, 3-dihydrothiem (3,2-c) quinoline (8.4 pts.), m.p. 57.5-58.5 deg. (petrol); HCl salt m.p. 210-1 deg. (EtOH).
|
