| 摘要 |
<p>The new title compounds, also useful as intermediates for the prepn. of pharmaceuticals, where acyl includes opt. substd. aliphatic, cycloaliphatic, aromatic and araliphatic acyl, amino includes free amino and opt. substd. hydrocarbylamino, and the quinazoline ring may also be further substd., and esp. compounds (I): (where Ac = 2-7C alkanoyl, R'o = H or alkyl, opt. substd. by halogen, OH, amino, alkylamino, dialkylamino, pyrrolidino, piperidino, opt. C-substd. or containing ring unsatd. at beta-position, piperazino, N-alkyl- or N-hydroxyalkyl piperazino, thiomorpholino, or morpholino, opt. C substd. or alkylphenyl opt. substd. in the ring by halogen, OH, alkoxy, amino, or alkyl and Ro = H, halogen alkyl, CF3 or alkoxy) are prepared by converting an appropriate 6-Y-substd. quinazoline into the desired compound by known methods, where Y is a group replaceable by a convertible into an amino group, with opt. elimination or esp. introduction of other substituents. Pref. Y=NO2 is reduced to -NH2.</p> |
