发明名称 |
Use of dna oligomers for inhibition of hiv by decreasing ribosomal frameshifting |
摘要 |
The invention relates to the use of antisense DNA oligomers to decrease the occurrence of ribosomal frameshifting required for the production of HIV enzymatic proteins when translating HIV messenger RNA, which should interfere with the production of virions and disrupt HIV life cycle. The antisense DNA oligomers are complementary to regions of the RNA of the small ribosomal subunit of mammalian cells, which are involved in the control of translation fidelity. |
申请公布号 |
AU2064495(A) |
申请公布日期 |
1995.10.23 |
申请号 |
AU19950020644 |
申请日期 |
1995.03.28 |
申请人 |
UNIVERSITE DE MONTREAL |
发明人 |
LEA BRAKIER-GINGRAS;PIERRE MELAN×ON;MARC C·TE;CATHERINE PAYANT |
分类号 |
C12N15/09;A61K31/70;A61K38/00;C07H21/04;C12N15/00;C12N15/113;C12R1/92 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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