| 摘要 |
<p>NEW MATERIAL:A compound shown by formula I [R<5>' is 1-10C alkyl, (substituted) phenyl, (substituted) alicyclic group, (substituted) phenyl 1-2C alkyl, etc.; R<1> is H or methyl; R2 is 5-8C alkyl, (substituted) alicyclic group, (substituted) phenyl, phenoxy or (substituted) 1-5C alkyl; R<3>' and R<4>' are 2-7C acyl, tri 1-7C hydrocarbon-silyl or group capable of forming acetal bond with O of OH; R<8>, R<8>' and R<8>'' are 1-7C alkyl or aryl(alkyl)]. EXAMPLE:A compound shown by formula II. USE:A raw material for producing prostacyclins. PREPARATION:A compound shown by formula III is heated with ruthenium trichloride.trihydrate and anhydrous potassium carbonate in methanol, exo double bond is isomerized, optionally a protecting group is converted to give a compound shown by formula IV. This compound is silylated into a compound shown by formula V and then reduced.</p> |
