发明名称 MOLECULES WITH ANTIBODY COMBINING SITES THAT EXHIBIT CATALYTIC PROPERTIES
摘要 An analog-ligand having a conformation that substantially corresponds to the conformation of a hydrolytic transition state of an amide or ester reactant ligand is used to produce receptor molecules of predetermined specificity. The receptor molecules include an antibody combining site that binds to a reactant ligand and thereby stabilizes the tetrahedral carbon atom of the amide or ester hydrolysis transition state of that reactant ligand to catalytically hydrolyze the reactant ligand at a predetermined site. 7889M D-48S
申请公布号 CA1312835(C) 申请公布日期 1993.01.19
申请号 CA19870546973 申请日期 1987.09.16
申请人 SCRIPPS CLINIC AND RESEARCH FOUNDATION 发明人 TRAMONTANO, ALFONSO;JANDA, KIM D.;LERNER, RICHARD A.
分类号 C12N15/02;A61K39/00;A61K47/48;B01J31/02;C07C67/00;C07C69/157;C07C213/00;C07C231/00;C07C233/54;C07C237/22;C07D207/46;C07D213/81;C07D215/32;C07D215/40;C07D311/16;C07F9/40;C07F9/42;C07F9/553;C07F9/58;C07F9/60;C07F9/6558;C07K16/44;C12N9/00;C12P21/00;C12P21/08;C12R1/91 主分类号 C12N15/02
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