发明名称 |
Multivalent agonists, partial agonists, inverse agonists and antagonists of the 5-HT3 receptors |
摘要 |
Disclosed are novel multi-binding compounds (agents) which bind 5-HT3 receptors. The compounds of this invention comprise a plurality of ligands each of which can bind to such receptors thereby modulating the biological processes/functions thereof. Each of the ligands is covalently attached to a linker or linkers which may be the same or different to provide for the multi-binding compound. The linker is selected such that the multi-binding compound so constructed demonstrates increased modulation of the biological processes mediated by the 5-HT3 receptor. |
申请公布号 |
AU4551499(A) |
申请公布日期 |
1999.12.30 |
申请号 |
AU19990045514 |
申请日期 |
1999.06.08 |
申请人 |
ADVANCED MEDICINE, INC. |
发明人 |
GUANG YANG;SUSAN MEIER-DAVIS;JOHN H GRIFFIN |
分类号 |
A61K31/00;A61K38/00;A61K39/00;A61K39/395;A61K39/44;A61K51/00;C07K2/00;C07K4/00;G01N33/53;G01N33/543;G01N33/566 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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