POLYPEPTIDE RELATED TO PROGRAMMED CELL DEATH IN HUMAN, DNA CODING THE SAME, VECTOR CONSISTING OF THE SAME DNA, HOST CELL TRANSFORMED WITH THE SAME VECTOR, ANTIBODY OF THE SAME POLYPEPTIDE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME POLYPEPTIDE OR THE SAME ANTIBODY

摘要

PURPOSE:To obtain a novel film-binding polypeptide (fragment) having a specific amino acid sequence, related to programmed death of human cells and useful as a therapeutic agent for infectious diseases, lowering or sthenia of immune function, tumor, etc., and its homologue. CONSTITUTION:A new film-binding polypeptide (PD-1) containing an amino acid sequence expressed by the formula I, related to programmed death of human cells and useful as a therapeutic agent for infectious diseases, lowering or sthenia of immune function, tumor and its homologue. This PD-1 is obtained by integrating DNA coding PD-l containing a base sequence of the formula I and the formula III into a vector to introduce into a host cell and manifest the vector. DNA coding PD-1 can be utilized for detection of PD-1 gene, studies on relationship between the gene and in vivo defense function, immune function or disease such as tumor and PD-1 can be utilized as a diagnosis and a therapeutic agent for PD-1-related diseases.