| 摘要 |
PROBLEM TO BE SOLVED: To provide a method and composition (including immunologic composition such as vaccine) targeting prevention and treatment of AIDS. SOLUTION: The presence of cytotoxic T-cells to the Rev and/or Tat protein in samples from a subject infected with immunodeficiency virus, particularly HIV in humans, is an indication of a stable disease condition and a favorable prognosis of lack of progression of disease. Immunogenic compositions containing at least one cytotoxic T-cell epitope of the Rev and/or Tat protein of an immunodeficiency virus, particularly HIV, or a vector encoding the T-cell epitope, may be used to prevent infection by disease caused by the immunodeficiency virus, by inducing, in the host, a specific cytotoxic T-cell response specific for the respective Rev and/or Tat proteins. COPYRIGHT: (C)2007,JPO&INPIT
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