发明名称 |
Sulphated hyaluronic acid and sulphated derivatives thereof covalently bound to polyurethanes, and the process for their preparation |
摘要 |
The present invention relates to the synthesis of a haemocompatible polymer, consisting of a polyurethane bound covalently to sulphated hyaluronic acid. These sulfated derivatives have anticoagulative, non-thrombogenic, antiviral and anti-inflammatory properties. They also have the ability to inhibit platelet adhesion, aggregation and activation. The invention is particularly advantageous in resisting the enzyme hyaluronidase, therefore ensuring anti-coagulant activities for longer periods of time when compared to similar compounds. This biocompatible polymer material is well suited for surgical or other medicinal uses.
|
申请公布号 |
US7345117(B1) |
申请公布日期 |
2008.03.18 |
申请号 |
US19990622146 |
申请日期 |
1999.02.24 |
申请人 |
BARBUCCI ROLANDO;CONSUMI MARCO;MAGNANI AGNESE;CALLEGARO LANFRANCO |
发明人 |
BARBUCCI ROLANDO;CONSUMI MARCO;MAGNANI AGNESE;CALLEGARO LANFRANCO |
分类号 |
A61L27/00;C08F283/04;A61L31/06;A61L31/10;A61L33/00;A61L33/06;C08G18/28;C08G18/34;C08G18/46;C08G18/72;C08G18/83 |
主分类号 |
A61L27/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|