发明名称 |
Derivatives of 1-(oxoaminoacetyl) pentylcarbamate as cathepsin K inhibitors for the treatment of bone loss |
摘要 |
Heterocycle substituted ketoamide derivatives of Formula (I), wherein the substitutes A, D, A and R are defined as in claim 1, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such heterocycle substituted ketoamide derivatives as well as method of using the same in the manufacture of medicaments for the treatment of disorders, including osteoporosis, associated with an imbalance between bone resorption and formation which can ultimately lead to fracture.
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申请公布号 |
US7402606(B2) |
申请公布日期 |
2008.07.22 |
申请号 |
US20040510469 |
申请日期 |
2004.10.07 |
申请人 |
SMITHKLINE BEECHAM CORPORATION |
发明人 |
BARRETT DAVID GENE;CATALANO JOHN G.;DEATON DAVID NORMAN;MILLER AARON BAYNE;RAY JOHN A.;SAMANO VICENTE |
分类号 |
A61K31/341;A61K31/365;A61K31/40;A61K31/4015;A61K31/4025;A61K31/404;A61K31/4155;A61K31/416;A61K31/4192;A61K31/4196;A61K31/42;A61K31/422;A61K31/4245;A61K31/427;A61K31/428;A61K31/433;A61K31/4439;A61K31/4709;A61K31/497;A61K31/5377;A61P19/00;A61P19/10;A61P43/00;C07D207/12;C07D207/26;C07D207/263;C07D207/27;C07D207/273;C07D207/48;C07D307/20;C07D307/33;C07D401/06;C07D403/06;C07D403/12;C07D405/06;C07D405/12;C07D409/06;C07D409/12;C07D413/06;C07D413/12;C07D413/14;C07D417/04;C07D417/06;C07D417/12;C07D417/14 |
主分类号 |
A61K31/341 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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