| 摘要 |
The present disclosure encompasses the protein BAH, and two cleavage prod ucts thereof, Vstat120 and Vstat40. The disclosure also describes the use of BAH, and two cleavage products thereof, Vstat120 and Vstat40, as an anti-an giogenic and anti-tumorigenic therapy for gliomas as well as its other types of cancer and conditions involving aberrant angiogenesis. One aspect of the disclosure therefore provides a polypeptide, derived from the protein BAH, comprising an integrin binding domain and a thrombospondin type 1 repeat. An other aspect of the disclosure provides methods of inhibiting the formation of a tumor sustained or disseminated by angiogenesis, comprising: contacting a developing tumor with one of the polypeptides derived from the protein BA M whereupon angiogenesis is inhibited, and thereby inhibiting the formation of the tumor. Another aspect of the disclosure is pharmaceutical composition s comprising a Vstat120 and Vstat40 polypeptide, or variants thereof, an at least one carrier for delivery to an animal or human patient.
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