| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to use of compound possessing activity of acid pump antagonizer, for preparing of drug for improving gastrointestinal motility in diseases associated with pathological gastrointestinal motility, for inducing III phase of migrating inter-digestive contractions (IMC). Said compound can be selected from group comprising: (S)-(-)-4-[(5,7-difluor-3,4-dihydro-2H-chromen-4-yl)oxy]-N,N,2-trimethyl-1H-benzimidazole-6-carboxamide;(-)-1-(2-methoxyethyl)-N,N,2-trimethyl-8-phenyl-1,6,7,8-tetragidrohromeno[7,8-d]imidazole-5-carboxamide; 1-[5-(2-fluorophenyl)-1-(pyridin-3-ilsul′fonil)-1H-pyrrol-3-yl]-N-metilmetanamin; 8-[{2,6-dimethylbenzyl}amino]-N-[2-hydroxyethyl]-2,3-dimetilimidazo[1,2-a]pyridine-6-carboxamide; 5,6-dimethyl-2-(4-fluoro-phenylamino)-4-(1-methyl-1,2,3,4-tetrahydroisoquinoline-2-yl)pyrimidine or pharmaceutically acceptable salts thereof. Invention also relates to pharmaceutical composition containing one of the above compounds.EFFECT: invention provides normalising and improving gastrointestinal motility.4 cl, 4 dwg, 4 ex |
