BACTERIUM OF THE GENUS CORYNEBACTERIUM AND MINICELLS DERIVED THEREFROM, AND USE THEREOF

摘要

The present invention relates to a drug-delivery carrier composition characterized by comprising a bacterium of the genus Corynebacterium and minicells derived from the bacterium of the genus Corynebacterium; the invention having the advantage of being relatively safer to use in the human body than other bacteria (e.g. E. coli, bacteria of the genus Salmonella and bacteria of the genus Bacillus) or than drug-delivery carriers derived from other bacteria. When the present invention comprises an anticancer drug protein expression construct (e.g. a protein expression recombinant vector), the invention provides a targeting technique via anticancer drug protein overexpression , effective in vivo protein expression regulation and target factor expression. Also, the present invention makes it possible to deliver a drug into the body in a stable fashion, and therefore makes it possible to maximise anticancer therapy effects.