| 摘要 |
The invention relates to a process for the preparation of trihydrated cefixime by reacting a functional derivative of N-protected (Z)-2-(2-aminothiazol-4-yl)-2-(tert-butoxycarbonylmethoxyimino)acetic acid with 7-amino-3-vinyl-3-cepheme-4-carboxylate of tert-butyl, or one of the salts thereof and, after removal of the protection group from the product thus obtained, by treating the product of the reaction with aluminium trichloride and anisole. This new process is carried out by using the new intermediate 7 beta -[(Z)-2-(2-aminothiazol-4-yl)-2-(tert-butoxycarbonylmethoxyimino)acetamido]-3-vinyl-3-cepheme-4-carboxylate of tert-butyl, optionally N-protected on the thiazolic amine. |
