ANTISENSE OLIGONUCLEOTIDES AND METHODS FOR THE TREATMENT OF SCHISTOSOMIASIS

摘要

Antisense oligonucleotides effective at inhibiting protein synthesis of schistosome worms are disclosed. It is shown that these oligonucleotides are efficiently taken up by the schistosome worm and may effectively kill the worms in vivo. Accordingly, these antisense oligonucleotides and methods of their administration may be useful for treating schistosomiasis.