Antiarrhythmic 1,4-benzoxazine derivs - viz N-amindalkyl-3,oxo-3,4-dihydro-2H-1,4-benzoxazine-carboxamides

摘要

New 1,4-benzoxazine derivs. of formula (I) and their acid-addn. salts (where R1 is H or 1-4C alkyl; R2 and R3 are H, 1-10C alkyl, aralkyl or phenyl; R4 is H or OHf R5 is H or 1-4C alkyl; R6 and R7 are H, 1-4C alkyl or aralkyl, or NR6R7 is a 4- to 6-membered heterocycle opt. contg. another heteroatom selected from O or NR11 (where R11 is H, 1-4C alkyl, or opt. alkyl-substd. phenyl), or R5 and R6 together can complete a 6-membered heterocycle A is 2-5C alkylene), have cardiovascular activity, esp. antiarrhythmic activity.