Process for the manufacture of pharmaceutical grade ranitidine base

摘要

A process for the manufacture of pharmaceutical grade ranitidine base(N-[2-[[[5-(Dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl-N'-methyl-2-nitro-1, 1-ethenediamine), is described. In-vitro and in-vivo pharmacological studies and acute toxicity studies indicate that it is as active and as safe as Form 2 ranitidine hydrochloride.