| 摘要 |
PURPOSE:To provide the subject compound useful as a drug, agricultural chemical, etc., especially as a synthetic intermediate for carcinostatic agents or antiviral agents. CONSTITUTION:A compound of formula I (R is O, S; Y is C, Ni; Z is H, 1-4C alkyl, trifluoromethyl; X is H, F, Cl; n is 1-10; m is 0,1; m is 1 when Y is C, and m is 0 when Y is N), e.g. 5-(trifluoromethyl)-6-methyluracil. The compound is produced by reacting a di(haloacyl)peroxide of formula II with a pyrimidine compound of formula III preferably in a solvent (e.g. 1,1,2- trichlorotrifluoroethane) at 0-150 deg.C. The peroxide compound and the piperidine compound are used in a molar ratio of 1:0.2-10. The compound of formula I can be readily obtained in a short time and in a high yield without a reaction catalyst and without a specific reaction device. |
