ARYLALKYLAMINES, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING SAME

摘要

Arylalkylamines of formula: …… in which: … …  - Y denotes …  - either a group Cy-N in which: … …  Cy denotes an optionally substituted phenyl, a C3-C7 cycloalkyl, a pyrimidinyl or a pyridyl, … …  - or a group …… in which … …  Ar denotes an optionally substituted phenyl, a pyridyl or a thienyl, …  x is zero or one, …  X denotes especially a hydroxyl, a C1-C4 alkoxy, a C1-C4 acyloxy, a carboxyl, a C1-C4 carbalkoxy, a cyano, a group -N-(X1)2 in which the groups X1 independently denote hydrogen or a C1-C4 alkyl, a group -S-X2 in which X2 denotes hydrogen or a C1-C4 alkyl group, a group …… in which Alk is a C1-C6 alkyl, or else X forms a double bond with the carbon atom to which it is bonded and with the neighbouring carbon atom in the heterocyclic ring, … …  - m is 2 or 3, …  - Ar' denotes an optionally substituted phenyl, a thienyl, a benzothienyl, a naphthyl or an indolyl, …  - R denotes hydrogen or a C1-C6 alkyl, …  - T denotes a group chosen from -CO- and -CW-NH-, W being an oxygen or sulphur atom, and …  - Z denotes either hydrogen or M or OM when T denotes the group -CO-, or M when T denotes the group -CW-NH-, M denotes a C1-C6 alkyl, a phenylalkyl, a pyridylalkyl, a naphthylalkyl, a pyridylthioalkyl, a styryl or an optionally substituted mono-, di- or tricyclic aromatic or heteroaromatic group, …  or one of its salts with inorganic or organic acids. … …Application: antagonists of neurokinin receptors.