发明名称 |
Controlled release dispenser comprising beneficial agent |
摘要 |
A dispenser is disclosed for delivering a beneficial agent in a hydrophilic carrier formulation to an animal in a rate-controlled manner. The dispenser comprises (1) a semipermeable housing defining an internal space, (2) at least one composition comprising a beneficial agent and a pharmaceutically acceptable hydrophilic carrier in the space, (3) an expandable hydrophilic driving member in the space, (4) a density member in the space, and (5) one exit passageway or a multiplicity of exit passageways in the housing for delivering the beneficial agent from the dispenser, the diameter of each exit passageway being of a size to maximize release of the beneficial agent by osmotic pumping and to minimize release of the beneficial agent by diffusion or erosion to substantially avoid mechanical agitation-dependent release of the beneficial agent.
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申请公布号 |
US5273752(A) |
申请公布日期 |
1993.12.28 |
申请号 |
US19910763393 |
申请日期 |
1991.09.19 |
申请人 |
ALZA CORPORATION |
发明人 |
AYER, ATUL D.;BURKOTH, TERRY L.;KUCZYNSKI, ANTHONY L.;DETERS, JOSEPH C. |
分类号 |
A61K9/00;(IPC1-7):A23K1/18 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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