发明名称 |
COMBINATION THERAPY USING RECEPTOR TYROSINE KINASE INHIBITORS AND ANGIOGENESIS INHIBITORS |
摘要 |
The invention relates to a combination therapy for the treatment of tumors and tumor metastases comprising administration of receptor tyrosine kinase antagonists/inhibitors, especially ErbB receptor antagonists, more preferably EGF receptor (Her 1) antagonists and anti-angiogenic agents, preferably integrin antagonists, optionally together with agents or therapy forms that have additive or synergistic efficacy when administered together with said combination of antagonists/inhibitors, such as chemotherapeutic agents and or radiation therapy. The therapy can result in a synergistic potential increase of the inhibition effect of each individual therapeutic on tumor cell proliferation, yielding more effective treatment than found by administering an individual component alone. |
申请公布号 |
WO02055106(A2) |
申请公布日期 |
2002.07.18 |
申请号 |
WO2001EP15241 |
申请日期 |
2001.12.21 |
申请人 |
MERCK PATENT GMBH;GOODMAN, SIMON;KREYSCH, HANS-GEORG |
发明人 |
GOODMAN, SIMON;KREYSCH, HANS-GEORG |
分类号 |
A61K45/06;A61K31/337;A61K31/704;A61K31/7064;A61K31/7068;A61K33/24;A61K38/00;A61K38/08;A61K39/395;A61K41/00;A61K47/48;A61P35/00;A61P35/04;A61P43/00;C07K16/30 |
主分类号 |
A61K45/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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