EFFICIENT SYNTHESIS OF FURAN SULPHONAMIDE COMPOUND USEFUL IN THE SYNTHESIS OF NEW IL-1 INHIBITORS

摘要

Efficient synthesis of furan sulfonamide compound of the formula (I) (I) encompasses reaction of compounds of formula II with Gringard reagent in reaction inert solution, whereas R1 is (C1-C6) alkyl. Compound of formula II is obtained by a reaction of compounds of formula III with the compounds of the formula IV, whereas R1 is (C1-C6) alkyl with reagent of chlorination and some acid purifier in inert solutions. The invention also includes new compound of a formula: (IV) whereas R1 is (C1-C6) alkyl, and Q is halo, hydroxy or amine.