beta-AMYLOID PEPTIDE AND METHOD FOR SCREENING THERAPEUTIC AGENT OR PROPHYLACTIC AGENT FOR ALZHEIMER'S DISEASE USING THE SAME

摘要

PROBLEM TO BE SOLVED: To provide an Aβ(βamyloid peptide) elucidating structural factors of aggregation of the Aβand expression of neural cytotoxicity and to provide a method for screening a therapeutic agent or a prophylactic agent for AD (Alzheimer's disease) utilizing the Aβ. SOLUTION: An Aβ42 is composed of 42 amino acid residues. The Aβ42 in which a turn structure betweenβsheet structures based on amino acid sequences before and after the 22- and 23-positions and further the 38- and 39-positions is introduced into the 22- and 23-positions and the 38- and 39-positions is prepared. COPYRIGHT: (C)2007,JPO&INPIT