发明名称 NOVEL 2-HETEROARYL SUBSTITUTED INDOLES 695
摘要 The present invention relates to novel 2-heteroaryl substituted indole de rivatives, precursors thereof, and therapeutic uses of such compounds, havin g the structural formula (Ia) below: and to their pharmaceutically acceptabl e salt, compositions and methods of use. Furthermore, the invention relates to novel 2-heteroaryl substituted indole derivatives that are suitable for i maging amyloid deposits in living patients, their compositions, methods of u se and processes to make such compounds. More specifically, the present inve ntion relates to a method of imaging amyloid deposits in brain in vivo to al low antemortem diagnosis of Alzheimer's disease as well as measureing clinic al efficacy of Alzheimer?s disease therapeutic agents.
申请公布号 CA2680055(A1) 申请公布日期 2008.09.12
申请号 CA20082680055 申请日期 2008.03.05
申请人 ASTRAZENECA AB 发明人 ARZEL, ERWAN;SWAHN, BRITT-MARIE;WENSBO, DAVID
分类号 C07D401/04;A61K31/4439;A61K31/497;C07D403/04 主分类号 C07D401/04
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