Verfahren zur Herstellung von N-(4-(N,N-Bis(2-chloräthyl))amino- phenyl)-phosphoramidsäure-bis(morpholid)

摘要

Chlorethyl group-containing phosphoramide derivatives. N-left brace 4- N,N-bis(2-chlorethyl) aminophenyl right brace- phosphoramide acid-bis(morpholide) is prepared by reacting N,N-bis-(2-chlorethyl)-p-phenylene diamine, PO2Cl and morpholine in any desired sequence, and opt. converting to non-toxic salts. It is an alkylating substance with cytostatic properties at low toxicity, and is used in malignant tumour therapy, partic. neoplasma of lymphatic diseases and immunological patterns associated with undesired cell increase, and can be given by mouth, injection or as suppositories.