MICROORGANISM THAT PRODUCES CEPHALOSPORIN C AND THE PROCESSING METHOD OF CEPHALOSPORIN C WITH USING IT

摘要

Cephalosporium acremonium (I) KFCC 10783 (II) for cephalosporin C (III) fermentation is screened with NTG treatment from (I) KFCC 10679 media containing 50 microgram per milliliter of nistatin. (I) KFCC 10784 (IV) is screened with 0.1 microgram per milliliter of amphotericin B. For (III) fermentation, (II) or (IV) is cultivating in the medium containing glucose-fructose mixture 4.5%, mixed oil 7.0%, peanut powder 2.5%, corn steep liquor 3.5%, corn meal 1.5%, gluten 3.0%. The final concentration of (III) is 40.2 gram per liter in (II), and 39.7 gram per liter in (IV).