发明名称 |
METHOD FOR MAKING LIPOSOMES OF ENHANCED ENTRAPPING CAPACITY TOWARD FOREIGN SUBSTANCES TO BE ENCAPSULATED |
摘要 |
<p>PCT No. PCT/EP91/00377 Sec. 371 Date Jun. 22, 1992 Sec. 102(e) Date Jun. 22, 1992 PCT Filed Dec. 9, 1992 PCT Pub. No. WO92/10166 PCT Pub. Date Jun. 25, 1992.Liposome vesicles are prepared containing water or very dilute solutions encapsulated therein. These "empty" liposomes are suspended in a carrier liquid containing, dispersed therein, substances of interest to be loaded into the vesicles and incubated for a period of time at temperatures above the lipids transition temperature, whereby loading by transmembrane permeation occurs in high yields.</p> |
申请公布号 |
GR3018506(T3) |
申请公布日期 |
1996.03.31 |
申请号 |
GR19950403587T |
申请日期 |
1995.12.21 |
申请人 |
BRACCO INTERNATIONAL B.V. |
发明人 |
SCHNEIDER, MICHEL;TOURNIER, HERVE;HYACINTHE, ROLAND;GUILLOT, CHRISTIAN;LAMY, BERNARD |
分类号 |
A61K9/00;A61K9/127;A61K47/48;A61K49/04;B01J13/02;(IPC1-7):A61K9/127 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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