发明名称 |
LEUKOTRIENE B 4 ANTAGONISTS. |
摘要 |
<p>This invention relates to compounds of Formula I and the stereoisomers and pharmaceutically acceptable salts thereof <IMAGE> +TR <IMAGE> wherein R is alkyl, alkenyl, alkynyl, or cycloalkylalkyl; R1 is alkyl; R2 is hydrogen, alkyl; R6 is alkyl; n is 1 to 5; p is 0 to 6; x is 0 or 2; and R4 and R5 are independently hydrogen or alkyl or together with N form a cycloalkylamine. The compounds of Formula I are leukotriene B4 antagonists and are useful as anti-inflammatory agents and in treating disease conditions mediated by LTB4.</p> |
申请公布号 |
GR3018322(T3) |
申请公布日期 |
1996.03.31 |
申请号 |
GR19950403300T |
申请日期 |
1995.12.07 |
申请人 |
G.D. SEARLE & CO. |
发明人 |
DJURIC, STEVAN, WAKEFIELD;DOCTER, STEPHEN, HERMANN;YU, STELLA, SIU-TZYY |
分类号 |
A61K31/00;A61K31/19;A61K31/192;A61K31/22;A61K31/222;A61K31/35;A61K31/352;A61K31/353;A61K31/40;A61P29/00;A61P43/00;C07C235/60;C07D295/192;C07D311/58;C07D311/66;(IPC1-7):C07D311/00;C07D295/18;A61K31/165;C07C235/62 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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