| 摘要 |
PURPOSE:To prepare the L-isomer of a phosphorus-containing amino acid, useful as an agricultural and horticultural fungicide and herbicide, by treating the racemic body of the phoshorus-containing amino acid with a specific microbial acylase which is inert to the D-isomer and specifically decomposes the acyl group of the L-isomer. CONSTITUTION:The racemic compound of N-acyl-D, L-2-amino-4-methylphosphinobutric acid (N-acyl-D,L-MPGA) of formula (R is acyl which may be substituted by halogen) is resolved into L-MPGA and N-acyl-D-MPGA by the action of cultured cells of microorganisms such as bacteria, actinomycetes, or molds, having acyl-decomposing activity, or their treated product, in an aqueous medium. The L-isomer and the D-isomer are separated each other by conventional fractionation. The microorganisms having acyl-decomposing activity, are bacteria belonging to Pseudomonas genus, Actinomycetes belonging to Streptomyces genus, or molds belonging to Aspergillus genus. |
