发明名称 |
Benzazepine derivatives, their pharmaceutical compositions and method of use |
摘要 |
Compounds of the formula <IMAGE> wherein A is -CH2-CH2-, -CH=CH-, -NH-CO-, -CH2-CO- or <IMAGE> where R7 is alkyl of 1 to 3 carbon atoms, and B is methylene, carbonyl or thiocarbonyl, or A is -CO-CO-, -N=CH-, <IMAGE> <IMAGE> where R8 is hydrogen or alkyl of 1 to 3 carbon atoms substituted by a phenyl, methoxyphenyl or dimethoxyphenyl, and B is methylene; E is n-alkylene of 2 to 4 carbon atoms optionally substituted by an alkyl of 1 to 3 carbon atoms, 2-hydroxy-n-propylene, 2-hydroxy-n-butylene or 3-hydroxy-n-butylene; G is n-alkylene of 1 to 5 carbon atoms optionally substituted by an alkyl of 1 to 3 carbon atoms, wherein one methylene group of an n-alkylene of 2 to 5 carbon atoms can be replaced by a carbonyl group, with the proviso that B represents a methylene or carbonyl group, or methylene-n-hydroxy-alkylene of 1 to 4 carbon atoms, where the methylene group is attached to the nitrogen atom; and R1 to R5 are simple substituents of various types; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as bradycardiacs.
|
申请公布号 |
US4490369(A) |
申请公布日期 |
1984.12.25 |
申请号 |
US19830547940 |
申请日期 |
1983.11.02 |
申请人 |
DR. KARL THOMAE GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG |
发明人 |
REIFFEN, MANFRED;HEIDER, JOACHIM;HAUEL, NORBERT;AUSTEL, VOLKHARD;EBERLEIN, WOLFGANG;KOBINGER, WALTER;LILLIE, CHRISTIAN;NOLL, KLAUS;PIEPER, HELMUT;KRUEGER, GERD;KECK, JOHANNES |
分类号 |
C07C59/64;C07D205/04;C07D223/16;C07D243/02;C07D243/04;C07D491/04;(IPC1-7):A61K31/55;C07D521/00 |
主分类号 |
C07C59/64 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|