Substituted 6-nitroquipazines, methods of preparation, and methods of use

摘要

Disclosed is a substituted 6-nitroquipazine of the formula <IMAGE> wherein R1, R2, R3, and R4 are each selected from the group consisting of H, Fl, CL, Br, I, CF3, CH2CH2F, CH3, CH2CH3, and -CH(CH3)2, and wherein one of R1, R2, R3, and R4 is other than H. Also disclosed is a method for measurement of serotonin uptake sites in a sample, in which a radioligand is incubated with a sample and then the radioactivity of the radioligand bound to the sample is determined, utilizing a radio labeled substituted 6-nitroquipazine as the radioligand. Also disclosed is a method of manufacture and method of use.